Not much point in doing that, just wanted to see if it would work.
Some instructions here.
Flatpak Heroic wouldn’t work, but the one from chaotic-aur works.
I used vm-curator to make the VM. Just edit the raw config, to add the options.
VM_CURATOR_VIDEO_ARGS=(-device virtio-vga-gl,blob=on,hostmem=8G,drm_native_context=on)
Works with the host as Arch Linux, and the guest as Arch Linux.
The mouse has issues though. Might need to change some setting. Or pass the mouse through.
Guess you could keep your main OS super clean if doing that. But Distrobox can be used to do that too.